Gut integrity in critical illness
نویسندگان
چکیده
منابع مشابه
Gut Microbiome and Host Defense Interactions during Critical Illness
For many years it has been hypothesized that the gut has an important detrimental role in promoting systemic inflammation and infection in the critically ill. During stress and mucosal hypoxia, the mucosa is damaged and host defenses break down causing translocation of bacteria and bacterial toxins which are thought to contribute to the overwhelming inflammation associated with sepsis and multi...
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Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in ...
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Critical illness in pregnancy increases maternal and fetal morbidity and mortality. The critical illness can be related to pregnancy per se, or can be secondary to a concurrent medical illness. Early identification and appropriate management results in good outcomes with a short ICU stay. Late identification and delayed therapy results in poor maternal & fetal outcomes with development of multi...
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PURPOSE OF REVIEW Tight junctions between adjacent epithelial cells are essential for the maintenance of compositionally distinct fluid compartments in various organs, such as the liver, lungs, kidneys, and intestine. These epithelial organs are commonly affected in the condition known as multiple organ dysfunction syndrome, which can complicate the clinical course of patients with sepsis or ot...
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The intestinal epithelial barrier is critical to limit potential harmful consequences from exposure to deleterious luminal contents on the organism. Although this barrier is functionally important along the entire gut, specific regional regulatory mechanisms involved in the maintenance of this barrier are poorly defined. Herein, we identified Gata4 as a crucial regulator of barrier integrity in...
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ژورنال
عنوان ژورنال: Journal of Intensive Care
سال: 2019
ISSN: 2052-0492
DOI: 10.1186/s40560-019-0372-6